Welcome to the Chudasama Group website
Based in University College London, our group is primarily focused on answering important biological questions through the application of Organic Chemistry. We do this by designing and tuning a variety of chemical tools (from chemoselective reagents with orthogonal “click” handles to photoswitchable azobenzenes) for the particular system we are studying.
We also work on novel methodologies based on aerobic C-H activation for the functionalisation of aldehydes and ethers with a plethora of azo-dicarboxylates and various alkenes/alkynes in a controlled manner.
News
| 05/02/24 | Welcome to the lab to Dr Ning Wang as a new post-doc! |
| 08/01/24 | Welcome to the lab to Mark, Maggie and Yijia for their Masters projects, Jonathon on his PhD rotation and to Suman as a new post-doc! |
| 18/12/23 | Congratulations to Mikesh and Lea on passing their PhD vivas; tremendous efforts by the pair of them! |
| 25/11/22 | After having a great time working together for ca. 5 years, it is a bittersweet moment to see Dr Richard Spears leave the lab – best of luck in the new job! |
| 26/09/22 | Welcome to new PhD students Charlie and Toby – both working on cutting-edge technologies in the area of protein modification! |
| 20/05/22 | Congratulations to Peter the PI on passing his PhD viva with flying colours – what a privilege it has been to work with you |
| 31/03/21 | Thank you and all best wishes for the future Fabien – it has been fantastic to host your fellowship at UCL – a real pleasure |
| 28/09/20 | Really looking forward to working with new PhD students Lea, Ioanna, Chapman and Mikesh – a strange time to start but confident they will all do great |
| 01/08/20 | After 8 years of working together, I am sad (both personally and academically) to no longer be working alongside the fantastic Antoine Maruani BUT I am very happy that he is now setting up his own lab! – he is going to do awesome! |
| 01/04/20 | Best of luck to graduating PhD students Andre and Marcos – both fantastic scientists and people |
| 24/09/19 | Great to have Nehaal Ahmed start his PhD with us today. Also a nice way to start a new collaboration Prof. Tom Sheppard |
| 29/07/19 | Mixed emotions – very proud of Joao on passing his viva today but gutted to see him leave; promise to help as best I can with the next steps |
| 17/01/19 | It was an absolute pleasure to give the Judith Howard Lecture at the University of Durham |
| 24/09/18 | Welcome to our new PhD student Alex Furby, and Master’s students Isaline Castan, Nehaal Ahmed and Fang Lan |
| 11/09/18 | Congratulations to PhD student André Shamsabadi on publishing his latest work in Chemical Communications |
| 07/06/18 | Very pleased that Peter Szijj will be joining our group on a Wellcome Trust studentship from September 2018 |
| 07/12/17 | Very pleased to have published our latest work on point-of-care diagnostics in ACS Nano |
| 06/10/17 | Congratulations to Max Lee on obtaining his PhD!! – well deserved, great scientist |
| 25/09/17 | Huge welcome to Faiza Javaid who has joined the group on a Wellcome Trust studentship |
| 23/05/17 | Congratulations to PhD student André Shamsabadi on being awarded the Tuffnell Prize |
| 06/05/17 | Been a real pleasure to share our recent work in Leiden and Boston at ATDC and PEGS Boston |
| 25/03/17 | Our key translation works have now been accepted in RSC Advances and OBC – optimised ADCS, in vivo validated |
| 07/12/16 | PhD students from the Chudasama Group scoop two 1st prizes at national-level poster competitions in two days |
| 30/11/16 | My favourite paper of the year thus far published in my favourite journal (Chemical Science); “springy” PD is here |
| 16/09/16 | New papers published in Chemical Science and Oncotarget |
| 08/09/16 | Great trip to Lisbon for the 1st ITN workshop |
| 16/08/16 | Dual modification leading to applications in photodynamic therapy – published in Photochemical & Photobiological Sciences |
| 15/06/16 | Very pleased to have our review on the dual modification of biomolecules accepted in OBC and highlighted as a hot article |
| 22/04/16 | Very pleased to have accepted André on a Graduate Research Scholarship, Calise on an EPSRC CASE award with MRCT, Marcos on a DTA Studentship, and João on an ITN grant as PhD students – look forward to working with you all in the near future |
| 01/04/16 | Congratulation to Max on winning the Bader Prize and to Antoine on winning another poster prize (!) |
| 21/03/16 | Very pleased to have papers accepted in OBC (2) – well done Eifion, a paper in ACS MacroLetters with the Battaglia Research Group, and an article in J Chem Res – well done Max & Antoine |
| 04/01/16 | Very pleased to start 2016 with papers accepted in OBC and RSC Advances, and a review published in Nature Chemistry |
| 01/01/16 | Welcome to our two new post-docs: Dan and Ben |
| 30/09/15 | Welcome to our new group members: Emma (PhD); Ihaab, Noyonika, Calise and André (Masters) |
| 15/09/15 | Delighted to see our two-in-one reagent published in Chemical Science – Congratulations Max and Antoine |
| 09/09/15 | Fantastic to have the support of UCL through an UCL Excellence Fellowship |
| 25/08/15 | Our antibody-based photodynamic therapeutic work has been published in Chemical Communications – Congratulations Antoine |
| 22/06/15 | Great to see that our latest Albumin work in OBC – Congratulations Mark, Eifion et al. |
| 01/06/15 | Great to see that our latest ADC work in Chemical Communications – Congratulations João, Mauricio et al. |
Highlighted Publications
Macrocyclic Dual-Locked “Turn-On” Drug for Selective and Traceless Release in Cancer Cells – Angewandte Chemie
The Nitrile Bis-Thiol Bioconjugation Reaction – JACS
Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels – Chemical Science
Chemical generation of checkpoint inhibitory T cell engagers for the treatment of cancer – Nature Chemistry
Modular Synthesis of Semiconducting Graft Co-polymers to Achieve “clickable” Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting – Advanced Materials
Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs) – Chemical Science
Modular Chemical Construction of IgG-like Mono- and Bispecific Synthetic Antibodies (SynAbs) – ACS Central Science
Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C–H activation and C–C bond formation – Chemical Science
Cysteine-To-Lysine Transfer Antibody Fragment Conjugation – Chemical Science
Post-translational site-selective protein backbone α-deuteration – Nature Chemical Biology
Forming next-generation antibody–nanoparticle conjugates through the oriented installation of non-engineered antibody fragments – Chemical Science
Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering – Chemical Science
A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy – Nature Communications
Recent advances in the construction of antibody–drug conjugates – Nature Chemistry
Next-generation disulfide stapling: Reduction and functional re-bridging all in one – Chemical Science